2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0473S10
    L-Tyrosine-d2-1 30811-19-9
    L-Tyrosine-d2-1 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-d2-1
  • HY-W015309S
    Decanoic acid-d3 102611-15-4 ≥99.0%
    Decanoic acid-d3 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects.
    Decanoic acid-d3
  • HY-W016498S
    Paraxanthine-d6 117490-41-2 ≥99.0%
    Paraxanthine-d6 is the deuterium labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
    Paraxanthine-d6
  • HY-12749
    Midodrine 42794-76-3 99.67%
    Midodrine is an α1-receptor agonist, for the treatment of dysautonomia and orthostatic hypotension.
    Midodrine
  • HY-17550
    Sunifiram 314728-85-3 99.89%
    Sunifiram (DM-235) is an ampakine-like compound and an agonist of AMPA receptor with oral activity. Sunifiram can increase the release of acetylcholine in the rat cerebral cortex and exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam (HY-B0585). Sunifiram is promising for research in neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's disease (AD).
    Sunifiram
  • HY-41268
    3-Methoxyphenylethylamine 2039-67-0
    3-Methoxyphenylethylamine is an organic compound that is used as an intermediate for pharmaceuticals, dyestuffs, and liquid crystal materials.
    3-Methoxyphenylethylamine
  • HY-77910
    4-(4-Bromophenyl)-4-hydroxypiperidine 57988-58-6 99.07%
    4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO) (HY-B0901) and is produced by N-dealkylation of BRO.
    4-(4-Bromophenyl)-4-hydroxypiperidine
  • HY-B0558
    Carbimazole 22232-54-8 ≥98.0%
    Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research.
    Carbimazole
  • HY-B0792
    CZC-54252 1191911-27-9 99.38%
    CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC-54252 attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of ~1 nM. CZC-54252 has a neuroprotective activity.
    CZC-54252
  • HY-B1047
    Carsalam 2037-95-8 99.82%
    Carsalam (Carbonylsalicylamide; 2H-1,3-benzoxazine-2,4-dione) is a salicylamide derivative and precursor compound. Carsalam is a nonsteroidal anti-inflammatory agent and can inhibit platelet aggregation.
    Carsalam
  • HY-B1083
    Modaline sulfate 2856-75-9 ≥99.0%
    Modaline sulfate is a MAO inhibitor, used in the treatment of depression.
    Modaline sulfate
  • HY-B1216
    Oxeladin citrate 52432-72-1 ≥98.0%
    Oxeladin citrate is an orally active and brain-penetrant cough suppressant as well as a selective sigma 1 receptor agonist (Ki = 25 nM). Oxeladin can be used for pulmonary diseases and stroke research.
    Oxeladin citrate
  • HY-N0775
    Isocorynoxeine 51014-29-0 99.52%
    Isocorynoxeine, an isorhynchophylline-related alkaloid, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM.
    Isocorynoxeine
  • HY-Y1176
    Isonipecotic acid 498-94-2 ≥98.0%
    Isonipecotic acid is a GABAA receptor partial agonist.
    Isonipecotic acid
  • HY-100928
    YS 035 hydrochloride 89805-39-0 99.15%
    YS 035 hydrochloride is a Ca2+ antagonist on cellular uptake and mitochondrial efflux of calcium ions. YS 035 hydrochloride inhibits Ca2+ uptake by muscle cells and inhibits Na+/Ca2+ exchange (Ki=28 µM). YS 035 hydrochloride is a useful tool for research on the mitochondrial Ca2+ transport.
    YS 035 hydrochloride
  • HY-113667
    ASN04885796 1032892-26-4 99.61%
    ASN04885796 (compound IV) is an GPR17 activator with an EC50 of 2.27 nM for GPR17 induced GTPγS binding. ASN04885796 has neuroprotective property and can be used for research of neurological diseases.
    ASN04885796
  • HY-121027
    Anagyrine 486-89-5 98.15%
    Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR, and Anagyrine can directly, without metabolism, desensitize nAChR.
    Anagyrine
  • HY-164566
    POSH-IN-2 348145-43-7 99.65%
    POSH-IN-2 (MIDI), a mitochondrial division inhibitor, is a DRP1 inhibitor that potently blocks mitochondrial fragmentation induced by cellular stresses and genetic mitochondrial lesions. POSH-IN-2 covalently interacts with DRP1-C367 to target DRP1 interaction with multiple receptors.
    POSH-IN-2
  • HY-165035
    Glucosylceramide (gaucher's spleen) 85305-87-9 ≥98.0%
    Glucosylceramides are sphingolipid molecules found in both neuronal and non-neuronal mammalian tissues, as well as in low quantities across various plant species. Elevated levels of glucosylceramides provide cellular protection and prepare certain cells for proliferation; however, they have also been linked to obesity-induced insulin resistance in mice and to neuronal deficits observed in neuronopathic Gaucher disease.
    Glucosylceramide (gaucher's spleen)
  • HY-16637R
    Folic acid (Standard) 59-30-3 98.39%
    Folic acid (Standard) is the analytical standard of Folic acid. This product is intended for research and analytical applications. Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.
    Folic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity